What is a brain tumor?
Brain Tumor
Brain tumors, or intracranial tumors, are neurological tumors that occur within the cranial cavity, including primary tumors originating from neuroepithelial tissue, meninges, germ cells, and peripheral nerves, as well as secondary tumors that metastasize intracranially from other systems. Brain tumors can occur at any age, but are more common in the 20 to 50 years of age.
In terms of types of brain tumors, gliomas account for about 60% of primary malignant intracranial tumors, meningiomas account for about 20% of intracranial tumors, and other types, including acoustic neuromas, pituitary adenomas, and craniopharyngiomas account for about 20% of tumors.
Globally, the incidence of brain tumors is about 32-40/100,000, half of which are malignant. In Malaysia, the incidence of brain tumors is 1.26/100,000 per year, accounting for 2% of all new cancer cases in the country.
Symptoms of Brain Tumors
Common symptoms of brain tumors include dizziness, headache, nausea, vomiting, visual disturbances, speech disturbances, mental abnormalities, abnormal sensation and movement disorders in the limbs, vision loss and visual field defects, seizures, and endocrine disorders.
Survival Rates for Brain Tumors
Gliomas of the brain are pathologically graded 1-4:
Grades 1-2 are low-grade gliomas, less malignant, with a survival period of 5-10 years
Grades 3-4 are high-grade gliomas, which are more malignant and prone to recurrence after surgery, with an average survival of about 14 months.
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Minimally Invasive Treatments for Brain Tumors
Radioactive Seed Implantation for Intracranial Tumors
Intracranial Tumor Seed Implantation, also known as "Particle Knife", is a therapeutic method to implant 125 iodine particles emitting low energy gamma rays into tumors via minimally invasive puncture technology under the guidance of CT, ultrasound, and other images, and to kill tumor cells fissioned at different periods in a sustained manner. 125 iodine particles radiate with a diameter of only 1.5 cm or so. The diameter of 125 iodine particles is only about 1.5cm, which only acts on the localized area and has the function of directional "blasting" to avoid damaging important intracranial tissues such as nerves and blood vessels.
Technical Advantages
1、Small trauma: no need for craniotomy, no damage to the important intracranial nerves, blood vessels, and other tissues.
2、Powerful killing: multiple seeds are implanted into the tumor tissues, and the radiation dose is 2-3 times that of the normal radiation dose, which is more efficient in killing tumor cells.
3、High quality of life: the seed implantation wound is as big as the eye of a needle, which does not affect bathing and exercise, and the patient can take normal activities after treatment.
4、Repeatability: the patient's body function recovers quickly, and the seed implantation treatment is still feasible when there is local recurrence or metastatic lesions.
Indications
Smaller primary tumors without any treatment
Inoperable primary brain tumors
Tumors for which the patient refuses radical surgery
Metastatic tumor lesions (single or multiple) or postoperative isolated tumor metastases lost to surgery
Localized dose supplementation for ineffective and insufficient external irradiation
Ar-He Knife Cryoablation of Intracranial Tumors
It is an important ablation technique. When argon is rapidly released in the tip of the needle, it can freeze the tumor lesion tissue to -120℃~-180℃ in more than ten seconds to form an ice ball, and the tumor tissue inside the ice ball will be "starved and cold", resulting in coagulative necrosis; when helium is rapidly released in the tip of the needle, it will be rapidly warmed up to 20℃~40℃, which will thaw and blast the hardened ice ball, thus achieving the effect of destroying the tumor tissue. The speed and time of cooling and warming, as well as the size and shape of the ice ball, can be set and controlled.
Technical advantages
1.Cryotherapy is less traumatic and quicker recovery
2.High safety, low risk
3.Less toxic side effects, less damage to normal tissues, repeatable
4. No need for surgery, but can get the same effect as surgery. Cryotherapy destroys tumor tissues with the treatment method of "extreme heat + extreme cold".
Indications
It is mainly indicated for cerebral glioma, meningioma and cavernous hemangioma, pituitary tumor, and so on.





Adjuvant Therapy with Traditional Chinese Medicine (TCM)
Chinese medicine treatment of brain tumors has a strong holistic concept and is often consider the characteristics of the patient's whole body rather than limiting itself to the cancer. TCM adjustments can correct certain disorders of the body, remove recurrence factors of the tumor, and reduce the chance of metastasis.
Chinese medicine is less harmful to healthy cells and generally does not cause new damage to physical strength by treating the cause of the disease itself. While the cancer improves, the physical strength of patient is gradually restored and the immune system is gradually strengthened.
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Traditional Treatments for Brain Tumors

  • Surgery

    The main methods of treating intracranial tumors is surgical removal to lower intracranial pressure, reduce tumor load, relieve symptoms, and create an opportunity for subsequent radiotherapy.

  • Radiotherapy

    It mainly includes three modalities: conventional radiotherapy, intratumoral radiotherapy, and stereotactic radiotherapy, and the appropriate modality is chosen according to the sensitivity of different tumors to radiation.

  • Chemotherapy

    It is usually used as an adjuvant treatment for malignant brain tumors, which can control the development rate of the disease and prolong the survival cycle of patients.

Minimally Invasive Therapy vs. Conventional Treatment

Minimally invasive therapy

1.No need for craniotomy, no damage to the important intracranial nerves, blood vessels, and other tissues.
2.Wide range of indications, preserving brain function to a large extent.
3.Less pain for patients, high quality of survival.
4.Fewer side effects and fewer complications.
5.Strong targeting, precise treatment, good efficacy.
6.Minimally invasive treatment, repeatable; different minimally invasive therapies can be superimposed to achieve a comprehensive effect.

  • Craniotomy

    1.High risk of surgical resection, which may produce complications such as stroke, functional area damage, bleeding, infection, and thrombosis.
    2.High trauma and pain for patients.
    3.Easy to recur and metastasize after surgery.
    4.Difficulty of surgery, cannot be repeated.

  • Radiotherapy

    1.While irradiating tumor tissues, radiation also produces toxic side effects, such as nausea, vomiting, etc.
    2.Small local irradiation dose, unsatisfactory therapeutic effect, and easy to recur.

  • Chemotherapy

    1.Regarding the chemotherapy process of most cancers, patients need 8-24 times of chemotherapy, which is a lot of times and a long treatment cycle 2.Chemotherapy is ineffective and has many toxic side effects, such as nausea, vomiting, hair loss, etc.
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Expert Introduction

Liu Yuansheng

Dean of Minimally Invasive Chief Specialist in Integrative Medicine Associate Physician
Member of the Standing Committee of the Expert Committee of the Minimally Invasive Tumor Therapy Committee of the China Anti-Cancer Association
Member of the Standing Committee of Interventional Minimally Invasive Professional Committee of China Medical Education Association
Member of the Standing Committee of the Professional Committee of Minimally Invasive Tumor Therapy, Guangzhou Anti-Cancer Association
Member of the Particle Therapy Professional Committee of the Minimally Invasive Tumor Therapy Professional Committee of the China Anti-Cancer Association

President Liu Yuansheng has been engaged in comprehensive minimally invasive interventional therapy and medical imaging diagnosis of solid tumors for more than 40 years. He is proficient in cryoablation, radiofrequency ablation, microwave ablation, nano-knife ablation, chemoablation, ultrasound focusing and photodynamic therapy, etc.; radioactive seed implantation and chemotherapy seed implantation, percutaneous intravascular drug infusion or/and embolization of tumors and related diseases in all parts of the body, and various kinds of intravascular and non-intravascular stenting and/or balloon dilatation and plasty. Proficient in all diagnostic imaging techniques. He completed more than 20,000 cases of various comprehensive minimally invasive interventional procedures.
Our Successful Cases
Radioactive Seed Implantation for Intracranial Tumors

Patient: 63 years old, male

2013-11, physical examination revealed a tumor in the lung.
2015-11, cranial MR examination suggested intracranial metastasis
2018-11, intracranial tumor progression, unable to receive follow-up treatment
2019-3, underwent brain tumor particle implantation
2019-7, intracranial tumor almost disappeared, normal life so far

Before treatment Head MRI, March 2019 (brain tumor circled in red)

After treatment In July 2019, the intracranial tumor had largely disappeared

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